A molecular MRI probe to detect treatment of cardiac apoptosis in vivo
Why the study?
Does ANX-SPIO molecular MRI probe detect early, reversible cardiac apoptosis in vitro and in vivo?
Population
Neonatal rat ventricular myocytes, cardiac fibroblasts, and mesenchymal stem cells in culture, and mouse…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for apoptosis imaging in cardiac models; leaves open translation and reversibility assessment in humans.
Structured PICO
Does ANX-SPIO molecular MRI probe detect early, reversible cardiac apoptosis in vitro and in vivo?
P
Population
Neonatal rat ventricular myocytes, cardiac fibroblasts, and mesenchymal stem cells in culture, and mouse heart in vivo with doxorubicin-induced apoptosis
I
Intervention
ANX-SPIO (superparamagnetic iron oxide conjugated to recombinant human Annexin-V) molecular MRI probe
O
Outcome
Detection of early cardiac apoptosis via T2*-weighted 3T MRI signal losssurrogate
ANX-SPIO molecular MRI can noninvasively detect early, reversible cardiac apoptosis in vivo, potentially identifying salvageable myocardium.
Cite This Study
Dash et al. (2011) studied this question.