The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse

Knockin mouse model with a premature stop codon in the nebulin gene, eliminating its C-terminal SH3 domain (NebΔSH3 mouse)

Genetic elimination of the C-terminal SH3 domain of nebulin

Wild-type mice (implied)

Structural and histological skeletal muscle abnormalities, gene expression, localization of interaction partners, and muscle mechanics (peak isometric stress, passive tensile stress, Young's modulus, force-frequency relationship, susceptibility to eccentric contraction-induced injury)surrogate