Why the study?
Does EV71 infection increase the risk of nervous system complications and death compared to CA16 or other enteroviruses in children hospitalized with HFMD?
Population
423 hospitalized children with hand, foot and mouth disease treated in Shengjing Hospital, Liaoning…
Comparison
Enterovirus 71 (EV71) infection vs Coxsackie A16 infection and other enterovirus…
Design
Cohort
Authors
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EV71 HFMD may warrant closer neurologic monitoring in hospitalized children; hypothesis-generating for targeted prevention trials.
Does EV71 infection increase the risk of nervous system complications and death compared to CA16 or other enteroviruses in children hospitalized with HFMD?
EV71 infection in children with HFMD is associated with faster disease progression, higher rates of severe nervous system damage, neurogenic pulmonary edema, and death compared to other enteroviruses.
Xu et al. (2012) studied this question.
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