Why the study?
Does intravenous or oral propafenone improve conversion to sinus rhythm in patients with recent-onset atrial fibrillation without heart failure?
Population
123 patients with recent-onset (< 72 hours) atrial fibrillation (AF) without heart failure
Comparison
Propafenone intravenously or in a single oral dose vs Placebo
Design
RCT, randomly treated
Follow-up
8 hours per phase
Authors
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IV propafenone enables rapid conversion in recent-onset AF; confirms oral loading efficacy by 4-8 hours.
Does intravenous or oral propafenone improve conversion to sinus rhythm in patients with recent-onset atrial fibrillation without heart failure?
Intravenous propafenone provides rapid conversion of recent-onset AF within 1 hour, whereas a single oral loading dose is highly effective by 4 to 8 hours.
Botto et al. (1998) studied this question.
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