Why the study?
Does a single oral dose of propafenone improve conversion to sinus rhythm in patients with recent onset atrial fibrillation without heart failure?
Does a single oral dose of propafenone improve conversion to sinus rhythm in patients with recent onset atrial fibrillation without heart failure?
A single oral loading dose of propafenone is safe and effective for converting recent-onset atrial fibrillation to sinus rhythm in patients without heart failure, suggesting routine hospital admission may be unnecessary.
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Propafenone was associated with higher conversion in recent-onset AF; hypothesis-generating and requires randomized confirmation before practice change.
Botto et al. (1996) studied this question.
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