Why the study?
Does a single loading oral dose of propafenone, flecainide, or digoxin improve conversion to sinus rhythm and affect the incidence of regular ventricular rhythms in patients with recent onset atrial fibrillation compared to placebo?
Population
243 patients with recent onset (< 72 hours) atrial fibrillation (AF), without heart failure
Comparison
Single loading oral dose of propafenone… vs Placebo
Design
RCT, randomly treated
Follow-up
4 hours
Authors
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Single-dose propafenone or flecainide converts recent-onset AF; confirms Class Ic efficacy and supports pill-in-the-pocket protocols in guidelines.
Does a single loading oral dose of propafenone, flecainide, or digoxin improve conversion to sinus rhythm and affect the incidence of regular ventricular rhythms in patients with recent onset atrial fibrillation compared to placebo?
Single oral loading doses of propafenone and flecainide are highly effective for acute conversion of recent-onset AF, and periods of regular tachycardia during conversion are expected and do not necessarily represent a proarrhythmic effect.
Botto et al. (1994) studied this question.
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