What question did this study set out to answer?

April 15, 1997Annals of Internal Medicine

Oral Propafenone To Convert Recent-Onset Atrial Fibrillation in Patients with and without Underlying Heart Disease

View Full Paper

Ask AI

Bookmark

Why the study?

Does a single 500-mg oral dose of propafenone improve conversion to sinus rhythm in hospitalized patients with recent-onset atrial fibrillation?

Key Points

To investigate the safety and efficacy of single-dose oral propafenone for converting recent-onset atrial fibrillation to sinus rhythm and determine the impact of underlying heart disease.
Randomized, single-blind, controlled trial conducted across 3 teaching hospitals involving 240 hospitalized patients with recent-onset atrial fibrillation.
Patients received either a single 500-mg oral dose of propafenone (n=119) or matching placebo (n=121).
Conversion rates to normal sinus rhythm were evaluated at 3 and 8 hours post-administration.
Propafenone demonstrated superior conversion to sinus rhythm compared to placebo at 3 hours (45% [54/119] vs. 18% [22/121], P < 0.001) and at 8 hours (76% [91/119] vs. 37% [45/121], P < 0.001).
At 8 hours, propafenone was effective in patients without heart disease (78% vs. 56% placebo, P = 0.02), with hypertension (70% vs. 27% placebo, P < 0.001), and with structural heart disease (81% vs. 17% placebo, P < 0.001).
Spontaneous conversion occurred at higher rates in patients without structural heart disease than in those with structural conditions.

Structured PICO

Does a single 500-mg oral dose of propafenone improve conversion to sinus rhythm in hospitalized patients with recent-onset atrial fibrillation?

Population

240 hospitalized patients with recent-onset atrial fibrillation, including those with and without underlying heart disease

Intervention

Propafenone (one 500-mg oral dose)

Comparator

Placebo

Outcome

Conversion rate to sinus rhythm at 3 and 8 hourssurrogate

A single 500-mg oral loading dose of propafenone is highly effective for converting recent-onset atrial fibrillation to sinus rhythm within 8 hours, regardless of underlying structural heart disease.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports single-dose oral propafenone for recent-onset AF conversion in hospital; extends efficacy to patients with structural heart disease.

Cite This Study

Giuseppe Boriani (1997) studied this question.

synapsesocial.com/papers/6a7cdb1b6e07fdc915aeb16c https://doi.org/10.7326/0003-4819-126-8-199704150-00006

Topics

Persistent AF management Atrial fibrillation Hypertension management Anticoagulation in AF

View Full Paper

Ask AI

Bookmark

Implication

Supports single-dose oral propafenone for recent-onset AF conversion in hospital; extends efficacy to patients with structural heart disease.

Oral Propafenone To Convert Recent-Onset Atrial Fibrillation in Patients with and without Underlying Heart Disease

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Oral Propafenone To Convert Recent-Onset Atrial Fibrillation in Patients with and without Underlying Heart Disease

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider