What question did this study set out to answer?

To determine whether intramyocardial pressure comprises both interstitial fluid pressure and myocardial fiber stress generated during ventricular contraction.

August 1, 1989AJP Heart and Circulatory Physiology

Intramyocardial pressure: interaction of myocardial fluid pressure and fiber stress

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Population

Conditioned dogs

Design

Preclinical

Authors

SRSina Y. RabbanyHofstra University JKJ. Yasha KreshAllegheny College ANAbraham NoordergraafHaverford College

Discussion

Member takes

Implication

Refines myocardial mechanics models in animals; leaves open translation to human ventricular wall stress and clinical relevance.

Key Points

To determine whether intramyocardial pressure comprises both interstitial fluid pressure and myocardial fiber stress generated during ventricular contraction.
Assessed intramyocardial pressure with a side-mounted strain gauge transducer and intramyocardial fluid pressure with a shielded fiber-optic transducer across multiple wall depths in conditioned dogs.
Evaluated physiological variations using inotropic agents (epinephrine, propranolol), mechanical interventions (aortic clamping, left anterior descending coronary artery ligation), and autonomic nerve stimulation.
Demonstrated a consistent transmural gradient across the left ventricular free wall for both intramyocardial pressure and intramyocardial fluid pressure.
Endocardial systolic intramyocardial fluid pressure matched left ventricular cavity pressure, whereas peak total intramyocardial pressure exceeded both chamber and fluid pressures.

Structured PICO

Population

Conditioned dogs

Intervention

Measurement of intramyocardial pressure (IMP) and intramyocardial fluid pressure (IFP) at various depths in the left ventricular free wall using specific transducers, under various inotropic, mechanical, and neural interventions

Outcome

Intramyocardial fluid pressure (IFP) and intramyocardial pressure (IMP) at various depths in the left ventricular free wallsurrogate

The study demonstrates that intramyocardial pressure is the sum of intramyocardial fluid pressure and fiber stress, explaining why peak IMP can exceed systolic left ventricular pressure.

Cite This Study

Rabbany et al. (1989) studied this question.

synapsesocial.com/papers/6a73dcd06acfb9d2a78dead1 https://doi.org/10.1152/ajpheart.1989.257.2.h357

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Intramyocardial pressure: interaction of myocardial fluid pressure and fiber stress

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Intramyocardial pressure: interaction of myocardial fluid pressure and fiber stress

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider