February 1, 1991Journal of VirologyOpen Access

The integrity of the stem structure of human immunodeficiency virus type 1 Tat-responsive sequence of RNA is required for interaction with the interferon-induced 68,000-Mr protein kinase

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Population

HIV-1-infected cells, stably transformed cell lines expressing TAR region, HeLa cell extract, and in…

Comparison

Wild-type TAR RNA stem structure vs Mutant TAR RNAs and low-affinity synthetic RNAs

Design

Preclinical

Authors

SRSophie RoyBristol-Myers Squibb (Germany)MAMichael B. AgyDuke University AHAra G. HovanessianDélégation Paris 5

Discussion

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Implication

TAR stem-PKR link is hypothesis-generating in animal models; leaves open any role in human HIV therapy.

Structured PICO

Population

HIV-1-infected cells, stably transformed cell lines expressing TAR region, HeLa cell extract, and in vitro-synthesized wild-type and mutant TAR RNAs

Intervention

Wild-type TAR RNA stem structure

Comparator

Mutant TAR RNAs and low-affinity synthetic RNAs

Outcome

Binding to and activation of P68 protein kinasesurrogate

The integrity of the HIV-1 TAR RNA stem structure is required for binding and activating the interferon-induced P68 protein kinase, which may play a role in viral replication.

Cite This Study

Roy et al. (1991) studied this question.

synapsesocial.com/papers/6a73dd46f4f9256fee8dea6c https://doi.org/10.1128/jvi.65.2.632-640.1991

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The integrity of the stem structure of human immunodeficiency virus type 1 Tat-responsive sequence of RNA is required for interaction with the interferon-induced 68,000-Mr protein kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The integrity of the stem structure of human immunodeficiency virus type 1 Tat-responsive sequence of RNA is required for interaction with the interferon-induced 68,000-Mr protein kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider