Population
293 cell lines, T-lymphocyte cell lines, and peripheral blood mononuclear cells infected with HIV-1
Comparison
HIV-1 viruses containing TAR mutations vs Wild-type HIV-1 virus
Design
Preclinical
Authors
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Cell-type differences in TAR dependence limit extrapolation from T-cell lines; leaves open context-specific roles for TAR in primary cells.
The HIV-1 TAR element is critical for viral gene expression and replication, but the magnitude of its requirement depends on the infected cell type.
Harrich et al. (1994) studied this question.
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