Why the study?
Does truncation of the TAR structure affect viral transcription, RNA processing, translation, or replication in SIVmac?
Does truncation of the TAR structure affect viral transcription, RNA processing, translation, or replication in SIVmac?
The complex TAR structure in SIVmac has no essential function in virus replication in vitro other than its role in Tat-mediated activation of transcription.
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TAR dispensability beyond Tat activation in SIV in vitro; leaves open essential roles in vivo or HIV pathogenesis.
Centlivre et al. (2008) studied this question.
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