Extent of Early Ischemic Changes on Computed Tomography (CT) Before Thrombolysis
Why the study?
Does baseline ASPECTS modify the effect of intravenous rt-PA on functional outcome and secondary hemorrhage in patients with acute stroke within 6 hours of onset?
Population
800 patients with acute stroke within 6 hours of symptom onset from the European-Australian Acute Stroke…
Comparison
Intravenous recombinant tissue plasminogen… vs Placebo
Design
Cohort, Randomized (in the original ECASS II trial)
Follow-up
90 days
Authors
Discussion
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Member takes
Implication
Baseline ASPECTS does not modify the efficacy of rt-PA on functional outcome in acute stroke, but an ASPECTS ≤7 identifies patients at substantially increased risk for thrombolytic-related parenchymal hemorrhage.
Structured PICO
Does baseline ASPECTS modify the effect of intravenous rt-PA on functional outcome and secondary hemorrhage in patients with acute stroke within 6 hours of onset?
P
Population
800 patients with acute stroke within 6 hours of symptom onset from the European-Australian Acute Stroke Study (ECASS) II
I
Intervention
Intravenous recombinant tissue plasminogen activator (rt-PA)
C
Comparator
Placebo
O
Outcome
Favorable outcome defined as modified Rankin Scale score 0 to 2 after 90 dayshard clinical
Baseline ASPECTS does not modify the efficacy of rt-PA on functional outcome in acute stroke, but an ASPECTS ≤7 identifies patients at substantially increased risk for thrombolytic-related parenchymal hemorrhage.
Cite This Study
Dzialowski et al. (2006) studied this question.