Immunosuppressive therapy, rather than the antipicornavirus agent pleconaril, improved symptoms in a CVID patient with chronic parechovirus-associated enteropathy, suggesting infection-related immune dysregulation.
Immunosuppression improved symptoms where pleconaril failed in CVID parechovirus enteropathy; hypothesis-generating for immune dysregulation and requires prospective validation.
A 14 year old common variable immunodeficiency patient developed severe protein-losing enteropathy. A chronic enteral infection with human parechovirus type 1 and norovirus was diagnosed. Treatment strategies aimed at virus eradication and providing supportive care were ineffective. The antipicornavirus agent pleconaril did not have any effect on viral replication. Symptoms improved on immunosuppressive therapy, suggesting infection-related immune dysregulation in an immunocompromised host.
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Ven et al. (2010) studied this question.
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