Why the study?
Takotsubo cardiomyopathy is typically triggered by emotional or physical stress, prompting this report of a case occurring without any identifiable stressor.
Takotsubo cardiomyopathy can present in patients without any identifiable preceding emotional or physical stressors.
Alerts clinicians to possible TCM in myasthenic crisis; extends known triggers but remains hypothesis-generating.
Takotsubo cardiomyopathy (TCM) is a cardiac condition that presents with features of acute myocardial infarction and transient systolic dysfunction without angiographic findings of obstructive coronary heart disease. Common presenting symptoms include acute substernal chest pain, dyspnea and syncope. It is usually triggered by recent emotional or physical stress such as head trauma, stroke, sepsis, overproduction of catecholamines such as pheochromocytoma or following Myasthenia crisis. We are here to report a case of TCM who does not have any identifiable emotional or physical stress prior to the event. The patient was a 76-year-old Caucasian female with a past medical history of hypertension who presented to the hospital with chest pain which initially was treated as non-ST elevation myocardial infarction (NSTEMI) with aspirin, ticagrelor and heparin infusion. Cardiac catheterization later revealed non-obstructive coronary artery disease but showed akinesis of inferior, apical and anterior walls with hyperdynamic basal segments indicating TCM.
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Tin et al. (2021) studied this question.