Why the study?
Does acute hyperinsulinemia inhibit myocardial protein degradation in men with coronary artery disease and insulin resistance?
Population
11 men with coronary artery disease and insulin resistance who had fasted for 12 to 16 hours.
Comparison
Constant infusion of insulin for 90 minutes… vs Basal state (prior to insulin infusion).
Follow-up
90 minutes
Authors
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Hypothesis-generating for hypertrophy mechanisms in insulin-resistant CAD; does not support practice change.
Does acute hyperinsulinemia inhibit myocardial protein degradation in men with coronary artery disease and insulin resistance?
Acute hyperinsulinemia markedly suppresses myocardial protein degradation in patients with cardiovascular disease and insulin resistance, providing a potential mechanism for the development of myocardial hypertrophy.
McNulty et al. (1995) studied this question.
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