Population
Perfused rat hearts (working preparations)
Comparison
Insulin in the presence of glucose, acetate, or… vs Different fuel substrates without insulin or…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether glucose-dependent insulin effects on cardiac protein degradation apply in vivo.
Insulin inhibits protein degradation in the perfused rat heart at physiological concentrations, an effect that appears to require the presence of glucose.
Sugden et al. (1982) studied this question.
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