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June 29, 2021International Journal of Environmental Research and Public HealthOpen Access

Early Left Ventricular Diastolic Dysfunction, Reduced Baroreflex Sensitivity, and Cardiac Autonomic Imbalance in Anabolic–Androgenic Steroid Users

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Why the study?

The effects of anabolic-androgenic steroid use on cardiac autonomic activity and its relationship with structural and functional cardiac remodeling were not adequately studied.

Does long-term androgen anabolic steroid use alter cardiac autonomic efficacy and structural/functional cardiac adaptations in strength-trained athletes?

Population

80 strength-trained athletes (40 AAS users, 40 nonusers) and 40 healthy nonathlete controls

Comparison

AAS-using strength-trained athletes vs nonuser strength-trained athletes vs healthy nonathletes

Authors

EKEvangelia KouidiΑΚΑντωνία ΚαλτσάτουMAMaria Anifanti

Discussion

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Member takes

Overview

AAS effects on athletes’ cardiac autonomic function remain poorly defined; leaves open links to remodeling.

Structured PICO

Does long-term androgen anabolic steroid use alter cardiac autonomic efficacy and structural/functional cardiac adaptations in strength-trained athletes?

P
Population
120 subjects: 80 strength-trained athletes (weightlifters and bodybuilders) and 40 healthy nonathletes. Group A: 40 androgen anabolic steroid (AAS) users; Group B: 40 nonuser strength-trained athletes; Group C: 40 healthy nonathletes.
I
Intervention
Long-term androgen anabolic steroids (AAS) use
C
Comparator
Nonuser strength-trained athletes and healthy nonathletes
O
Outcome
Baroreflex sensitivity (BRS), short heart rate variability (HRV) modulation, and echocardiographic parameters (LV mass index, LV ejection fraction, tissue Doppler imaging measurements)surrogate

Long-term anabolic-androgenic steroid use in strength-trained athletes is associated with altered cardiovascular autonomic modulation and early left ventricular diastolic dysfunction.

Cite This Study

Kouidi et al. (2021) studied this question.

synapsesocial.com/papers/6a73f4a09af59817ccbe8e6dhttps://doi.org/10.3390/ijerph18136974
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anabolic Steroid Abuse is Associated With a Dysfunction of the Autonomic System2024
  2. 2Left ventricular early myocardial dysfunction after chronic misuse of anabolic androgenic steroids: a Doppler myocardial and strain imaging analysis2006 · 183 citations
  3. 3Differences in Nervous Autonomic Control in Response to a Single Session of Exercise in Bodybuilders Using Anabolic Androgenic Steroids2021
  4. 4Cardiac structure and function in anabolic-androgenic steroid users: a 16-year follow-up study2025
  5. 5Prospective Echocardiographic Assessment of Androgenic-Anabolic Steroids Effects on Cardiac Structure and Function in Strength Athletes2003 · 71 citations