November 1, 1978Circulation
Effect of sublingual nitroglycerin on regional flow in patients with and without coronary disease.
Why the study?
Does sublingual nitroglycerin alter regional coronary flow and coronary resistance differently in patients with coronary artery disease compared to those with normal coronary arteries?
Population
20 patients, including 12 with coronary artery disease and 8 with normal coronary arteries. The CAD group…
Comparison
Sublingual nitroglycerin vs Baseline and comparison between CAD and NCA…
Design
Cohort
Authors
Discussion
Loading...
Member takes
Implication
Supports nitroglycerin-mediated redistribution in LAD-limited CAD; leaves open outcome impact in prospective studies.
Structured PICO
Does sublingual nitroglycerin alter regional coronary flow and coronary resistance differently in patients with coronary artery disease compared to those with normal coronary arteries?
P
Population
20 patients, including 12 with coronary artery disease (CAD) and 8 with normal coronary arteries (NCA). The CAD group included a subgroup of 6 patients with disease limited to the anterior descending artery.
I
Intervention
Sublingual nitroglycerin
C
Comparator
Baseline (resting state prior to nitroglycerin administration) and comparison between CAD and NCA patient groups
O
Outcome
Indices of regional coronary flow (coronary sinus flow [CSF] and great cardiac vein flow [GCVF]) and coronary resistance (total CR and anterior regional CR [CRANT])surrogate
Sublingual nitroglycerin redistributes coronary blood flow from normally perfused to hypoperfused regions in patients with specific patterns of coronary artery disease.
Cite This Study
Mehta et al. (1978) studied this question.