Why the study?
Does sublingual nitroglycerin alter echocardiographic measures of cardiac performance in patients with coronary artery disease and non-dyskinetic left ventricular contraction?
Population
8 patients with coronary artery disease and symmetrical (non-dyskinetic) left ventricular contraction
Comparison
Nitroglycerin 0.6 mg sublingually vs Baseline (before administration)
Design
Case_series
Follow-up
3 minutes
Authors
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Should not change practice in CAD; Level 5 case leaves open generalizability of nitroglycerin effects on LV performance.
Does sublingual nitroglycerin alter echocardiographic measures of cardiac performance in patients with coronary artery disease and non-dyskinetic left ventricular contraction?
Sublingual nitroglycerin improves ejection fraction and cardiac output in CAD patients, likely due to decreased preload and afterload rather than a true increase in contractility.
Harðarson et al. (1976) studied this question.
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