Why the study?
Does 0.6 mg sublingual nitroglycerin improve left ventricular systolic time interval responses to exercise in patients with angina?
Population
20 subjects (10 patients with angina and 10 normal controls)
Comparison
0.6 mg sublingual nitroglycerin vs Baseline/no nitroglycerin
Follow-up
Immediate (during and after a 4-min exercise step test)
Authors
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May support noninvasive nitrate efficacy assessment in angina; leaves open outcome prediction and practice change.
Does 0.6 mg sublingual nitroglycerin improve left ventricular systolic time interval responses to exercise in patients with angina?
Sublingual nitroglycerin normalizes abnormal left ventricular systolic time interval responses to exercise in patients with angina, providing a noninvasive method to evaluate nitrate efficacy.
Harris et al. (1973) studied this question.
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