June 29, 2014Journal of Hypertension
Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient
Why the study?
Do lower SBP and LDL-C targets reduce the risk of recurrent stroke and cognitive decline in older hypertensive patients with a recent stroke or TIA?
Population
7,500 patients aged at least 65 years with hypertension and a stroke or transient ischaemic attack 1-6…
Comparison
Antihypertensive and statin treatments aiming… vs Antihypertensive and statin treatments aiming…
Design
Other, 3 × 2 factorial design, Outcomes adjudicated by committees blind to…
Follow-up
mean 4-year
Authors
Discussion
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Member takes
Implication
Optimal post-stroke BP and LDL targets remain undefined in older patients; this trial protocol will test intensive lowering to address the gap.
Structured PICO
Do lower SBP and LDL-C targets reduce the risk of recurrent stroke and cognitive decline in older hypertensive patients with a recent stroke or TIA?
P
Population
7,500 patients aged at least 65 years (2,500 in Europe, 5,000 in China) with hypertension and a stroke or transient ischaemic attack 1-6 months before randomization.
I
Intervention
Antihypertensive and statin treatments aiming for lower SBP targets (<135-125 mmHg or <125 mmHg) and a lower LDL-C target (<1.8 mmol/l).
C
Comparator
Antihypertensive and statin treatments aiming for a higher SBP target (<145-135 mmHg) and a higher LDL-C target (2.8-1.8 mmol/l).
O
Outcome
Time to stroke (fatal and non-fatal)hard clinical
This protocol outlines a large-scale trial to determine the optimal blood pressure and LDL-cholesterol targets for preventing recurrent stroke and cognitive decline in older hypertensive patients.
Cite This Study
Zanchetti et al. (2014) studied this question.