Population
Cells microdissected from the rat medullary raphe and maintained in primary cell culture for 13-70 days
Design
Preclinical
Follow-up
13-70 days in culture
Authors
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Serotonergic medullary neurons may sense CO2 in rodents; leaves open translation to human ventilatory control.
Demonstrates that acidosis-stimulated neurons of the medullary raphe are serotonergic, supporting their role as central chemoreceptors in initiating homeostatic responses to blood CO2 changes.
Wang et al. (2001) studied this question.
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