Population
Rat carotid body (in vitro model)
Comparison
Angiotensin II with or without AT1 receptor… vs Baseline activity / antagonist alone
Design
Preclinical
Authors
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May inform chemoreflex mechanisms in experimental hypertension; leaves open translation to human cardiorespiratory control.
Angiotensin II directly alters carotid chemoreceptor afferent activity via AT1 receptors located on glomus cells, providing a mechanism for humoral fluid and electrolyte signals to influence cardiorespiratory function.
Andrew M. Allen (1998) studied this question.
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