June 1, 2002AJP Heart and Circulatory Physiology
Parasympathetic effects on cardiac electrophysiology during exercise and recovery
Population
9 subjects with implanted dual-chamber devices and normal left ventricular function, mean age 59 +/- 18 years.
Comparison
Parasympathetic blockade with atropine during… vs Absence of atropine.
Design
Other
Authors
Discussion
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Member takes
Implication
Heterogeneous parasympathetic effects during exercise may influence arrhythmia risk; leaves open whether site-specific modulation warrants targeted interventions.
Structured PICO
P
Population
9 subjects with implanted dual-chamber devices and normal left ventricular function, mean age 59 +/- 18 years.
I
Intervention
Parasympathetic blockade with atropine during noninvasive programmed stimulation (NIPS) across multiple bicycle exercise sessions.
C
Comparator
Absence of atropine (baseline state during the same exercise and recovery protocols).
O
Outcome
Parasympathetic effect (difference between absence and presence of atropine) on sinus cycle length, atrioventricular (AV) block cycle length, AV interval, and ventricular effective refractory period at rest, during exercise, and in early recovery.surrogate
Parasympathetic tone exerts distinct and poorly correlated electrophysiological effects on the sinus node, AV node, and ventricle during exercise and recovery.
Cite This Study
Kannankeril et al. (2002) studied this question.