Key Points
- This research investigates the role of adipose tissue dysfunction and adipokine secretion in nascent metabolic syndrome.
- Analyzed adipokine levels and inflammation markers in subjects with nascent metabolic syndrome.
- Examined subcutaneous adipose tissue for macrophage recruitment and crown-like structures.
- Compared plasma adipokine levels between subjects with nascent MetS and healthy controls.
- Increased levels of SAT-secreted and plasma adipokines observed in nascent MetS, including IL-1, IL-6, and leptin.
- Significant macrophage recruitment in subcutaneous adipose tissue with crown-like structures identified.
- Decreased plasma adiponectin and SAT omentin-1 levels in subjects with nascent MetS.
Structured PICO
PPopulationSubjects with nascent metabolic syndrome (MetS) uncomplicated by type 2 diabetes mellitus (T2DM) and/or cardiovascular disease (CVD)
OOutcomeAdipose tissue dysregulation and aberrant adipokine secretionsurrogate
Subcutaneous adipose tissue dysfunction and aberrant adipokine secretion in nascent metabolic syndrome contribute to low-grade inflammation and insulin resistance, driving the increased risk of T2DM and CVD.