September 11, 2009Circulation ResearchOpen Access

Spontaneous Calcium Oscillations Regulate Human Cardiac Progenitor Cell Growth

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Structured PICO

Population

c-kit-positive human cardiac progenitor cells (hCPCs) and transgenic mice with enhanced green fluorescent protein under the control of the c-kit promoter

Intervention

Induction of Ca2+ oscillations in hCPCs before their intramyocardial delivery to infarcted hearts

Outcome

Cell cycle entry, 5-bromodeoxyuridine incorporation, engraftment, and expansion of cells promoting the generation of a large myocyte progenysurrogate

IP3R-mediated Ca2+ mobilization controls human cardiac progenitor cell growth and enhances their regenerative potential in infarcted hearts.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May inform hCPC optimization strategies; hypothesis-generating in animal models, leaves open human translation.

Cite This Study

Ferreira‐Martins et al. (2009) studied this question.

synapsesocial.com/papers/6a7405b8bbad068246a8cc03 https://doi.org/10.1161/circresaha.109.206698

View Full Paper

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Spontaneous Calcium Oscillations Regulate Human Cardiac Progenitor Cell Growth

Structured PICO

Discussion

Implication

Cite This Study

Spontaneous Calcium Oscillations Regulate Human Cardiac Progenitor Cell Growth

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider