Why the study?
Does prolonged mechanical load via pulmonary artery constriction induce capillary and mast cell proliferation in the adult rat heart?
Population
Rats at 3 months of age
Comparison
Constriction of the pulmonary artery to produce… vs Unconstricted state
Design
Preclinical
Follow-up
200 days
Authors
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Hypothesis-generating for load-induced RV angiogenesis and mast cell hyperplasia; extends rodent models but leaves human translation open.
Does prolonged mechanical load via pulmonary artery constriction induce capillary and mast cell proliferation in the adult rat heart?
Prolonged mechanical load in the adult rat heart induces right ventricular hypertrophy accompanied by capillary proliferation and mast cell hyperplasia.
Olivetti et al. (1989) studied this question.
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