Why the study?
Does human epicardial adipose tissue express GLP-1 and GLP-2 receptors?
Population
8 subjects with coronary artery disease and type 2 diabetes mellitus undergoing elective cardiac surgery
Comparison
Evaluation of epicardial adipose tissue (EAT) vs Subcutaneous adipose tissue (SAT)
Design
Preclinical
Authors
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EAT GLP-1/2 receptor expression may inform agonist targeting; leaves open clinical effects and requires prospective validation.
Does human epicardial adipose tissue express GLP-1 and GLP-2 receptors?
This study provides the first evidence that human epicardial adipose tissue expresses both GLP-1 and GLP-2 receptors, suggesting a potential direct target for these pharmacological agents.
Iacobellis et al. (2017) studied this question.
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