Why the study?
Does continuous versus intermittent dosing of dofetilide alter QT interval responsiveness in healthy male volunteers?
Population
Healthy male volunteer subjects
Comparison
Dofetilide 1.0 mg twice daily continuously for… vs Matching placebo capsules
Design
RCT, randomized into three groups, single-blinded, placebo-controlled
Follow-up
24 days
Authors
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Continuous dofetilide dosing attenuates QTc responsiveness by day 5; extends evidence for steady-state modeling over single-dose extrapolation in arrhythmia management.
Does continuous versus intermittent dosing of dofetilide alter QT interval responsiveness in healthy male volunteers?
Continuous dosing of dofetilide leads to a stable and predictable QT interval response after 5 days, with less responsiveness at steady state compared to the first dose.
Allen et al. (2002) studied this question.
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