Why the study?
Does dofetilide alter QT-interval duration and dispersion at various heart rates in healthy subjects?
Does dofetilide alter QT-interval duration and dispersion at various heart rates in healthy subjects?
Dofetilide prolongs the QT interval in healthy subjects with some reverse rate dependence, but does not increase QT dispersion.
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Alerts clinicians to greater QT prolongation at slower rates during dofetilide initiation; confirms reverse rate dependence without dispersion increase.
́molis et al. (1996) studied this question.
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