Fatty Liver Is Associated With Dyslipidemia and Dysglycemia Independent of Visceral Fat: the Framingham Heart Study
Why the study?
Is fatty liver associated with dyslipidemia and dysglycemia independent of visceral fat in a community-based sample?
Population
2,589 individuals from the community-based Framingham Heart Study
Comparison
Presence of fatty liver vs Individuals without fatty liver
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Fatty liver may confer additional metabolic risk beyond visceral fat; hypothesis-generating and should not yet change practice.
Structured PICO
Is fatty liver associated with dyslipidemia and dysglycemia independent of visceral fat in a community-based sample?
P
Population
2,589 individuals from the community-based Framingham Heart Study
I
Intervention
Presence of fatty liver (measured by multidetector computed tomography of the abdomen)
C
Comparator
Individuals without fatty liver
O
Outcome
Cardio-metabolic risk factors (diabetes, metabolic syndrome, hypertension, impaired fasting glucose, insulin resistance, triglycerides, systolic blood pressure, diastolic blood pressure, HDL, and adiponectin levels)surrogate
Fatty liver is highly prevalent and independently associated with dysglycemia and dyslipidemia, even after adjusting for visceral adipose tissue and other obesity measures.
Cite This Study
Speliotes et al. (2010) studied this question.