Why the study?
Does flecainide reduce the incidence of class III-induced torsades de pointes in an animal model of acquired long QT syndrome?
Population
24 chloralose-anaesthetized rabbits (animal model of acquired long QT syndrome)
Comparison
Flecainide followed by concomitant infusion of… vs Vehicle followed by concomitant infusion of…
Design
Preclinical, pretreated at random
Authors
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Supports flecainide investigation for class III-induced torsades; leaves open translation beyond this rabbit model.
Does flecainide reduce the incidence of class III-induced torsades de pointes in an animal model of acquired long QT syndrome?
Flecainide dose-dependently reduces the risk of class III-induced torsades de pointes in a rabbit model of acquired long QT syndrome by attenuating delayed repolarization.
Hallman et al. (1995) studied this question.
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