Key result
Flecainide acetate administration in dogs with recent myocardial infarction increased the incidence of ventricular fibrillation during acute ischemia compared to saline (83% vs 36%, p<0.05).
Why the study?
Does flecainide acetate prevent ventricular tachyarrhythmia and fibrillation in dogs with recent myocardial infarction?
Population
Urethane-anesthetized dogs with recent myocardial infarction
Comparison
Intravenous flecainide acetate vs Saline
Design
Preclinical
Authors
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Flecainide increases VF risk during post-MI ischemia; challenges antiarrhythmic benefit and leaves open human translation.
Does flecainide acetate prevent ventricular tachyarrhythmia and fibrillation in dogs with recent myocardial infarction?
Absolute Event Rate: 83% vs 36%
p-value: p=<0.05
In a post-myocardial infarction dog model, flecainide acetate failed to prevent ventricular tachycardia and demonstrated proarrhythmic effects by increasing the risk of ventricular fibrillation during acute ischemia.
Lynch et al. (2008) studied Recent myocardial infarction. Flecainide acetate vs. Saline was evaluated on Development of ventricular fibrillation during acute posterolateral ischemia (p=<0.05). Flecainide acetate administration in dogs with recent myocardial infarction increased the incidence of ventricular fibrillation during acute ischemia compared to saline (83% vs 36%, p<0.05).
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