Why the study?
Does flecainide acetate reduce ventricular arrhythmias in an ischemic porcine heart model?
Population
Anesthetized, open-chest pigs with provoked ventricular arrhythmias via left anterior descending coronary…
Comparison
Flecainide acetate 2 mg/kg vs Untreated control animals
Design
Preclinical
Follow-up
30 minutes
Authors
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Flecainide attenuates arrhythmias in partial but not complete porcine ischemia; hypothesis-generating and should not guide clinical use.
Does flecainide acetate reduce ventricular arrhythmias in an ischemic porcine heart model?
Flecainide reduces ventricular arrhythmias during partial ischemia but depresses myocardial contractility and fails to prevent ventricular fibrillation during complete coronary occlusion in a porcine model.
Verdouw et al. (1979) studied this question.
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