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December 1, 2000Microbiology and Molecular Biology ReviewsOpen Access

Cytopathogenesis and Inhibition of Host Gene Expression by RNA Viruses

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Population

RNA viruses (picornaviruses, influenza viruses, and rhabdoviruses) and host cells

Design

Review

Authors

DLDouglas S. LylesWake Forest University

Discussion

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Overview

May guide antiviral strategies targeting host shutoff; leaves open clinical validation and therapeutic translation.

Structured PICO

P
Population
RNA viruses (picornaviruses, influenza viruses, and rhabdoviruses) and host cells

This review highlights that viral cytopathogenesis involves a critical balance between host antiviral responses and viral inhibition of host gene expression, which ultimately determines viral tissue tropism.

Cite This Study

Douglas S. Lyles (2000) studied this question.

synapsesocial.com/papers/6a742417e50bdaa0a433f84fhttps://doi.org/10.1128/mmbr.64.4.709-724.2000
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  4. 4The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A)1994 · 239 citations
  5. 5Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro1994 · 148 citations