Why the study?
Does daytime administration of oxprenolol effectively reduce blood pressure across the entire circadian cycle in ambulatory hypertensive subjects?
Does daytime administration of oxprenolol effectively reduce blood pressure across the entire circadian cycle in ambulatory hypertensive subjects?
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Daytime dosing of oxprenolol lowers daytime blood pressure but does not provide adequate 24-hour blood pressure control, particularly during the night and early morning.
Both systolic and diastolic blood pressure show a well defined circadian variation in ambulatory hypertensive subjects. 2. Blood pressure is highest in the mid-morning (10.00 hours) and lowest during sleep at 03.00 hours. 3. Treatment with oxprenolol (taken during the day) reduces daytime blood pressure but is less effective during the night and early morning.
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Craig et al. (1978) studied this question.
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