Why the study?
Does marine fish oil supplementation improve in vitro small artery endothelial function in hypercholesterolemic patients?
Population
28 subjects: 16 hypercholesterolemic patients and 12 age- and sex-matched control subjects.
Comparison
Marine fish oil 5 capsules BID for 3 months vs Placebo for 3 months
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
3 months
Authors
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Supports fish oil for endothelial improvement in hypercholesterolemia; extends mechanistic evidence for its cardiovascular benefits.
Does marine fish oil supplementation improve in vitro small artery endothelial function in hypercholesterolemic patients?
Marine fish oil supplementation for 3 months significantly improves endothelial function in peripheral small arteries of hypercholesterolemic patients, providing a potential mechanism for cardiovascular benefit.
Goode et al. (1997) studied this question.
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