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The research aims to derive genetics by formulating it through basic principles without primitive biological terms.

August 6, 2026Open Access

Genetics and the Genome: Inheritance and Variation of Information Topology (Volume II of the Axiomatization of Biology in the Global‑Realism Framework) Abstract

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The research aims to derive genetics by formulating it through basic principles without primitive biological terms.
Construct genes from sequence topology and molecular recognition principles.
Quantify the fidelity of semiconservative replication using thermodynamic factors.
Unify regulation as gated occupancy and sequence-dependent energy barriers.
Proves that semiconservative replication is uniquely defined by antiparallel duplex templating with quantified fidelity.
Establishes operator chains that effectively translate DNA topology into proteins, with specific energy considerations.
Reinterprets classical genetic concepts through statistical mechanics, ensuring a thermodynamic foundation.

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Volume II of global-realism biology program explores genetics as an extension of fundamental physical laws.

Jianming Wang (2026) studied this question.

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