What question did this study set out to answer?

To derive genetics, genomes, and inheritance mechanisms directly from physical, chemical, and nonequilibrium thermodynamic principles without introducing them as primitive biological assumptions.

August 14, 2026Open Access

Genetics and the Genome: Inheritance and Variation of Information Topology (Volume II of the Axiomatization of Biology in the Global‑Realism Framework)

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To derive genetics, genomes, and inheritance mechanisms directly from physical, chemical, and nonequilibrium thermodynamic principles without introducing them as primitive biological assumptions.
Constructed genes, alleles, and genomes mathematically from sequence topology, molecular recognition, and nonequilibrium thermodynamics.
Factorized transcription and translation into operator chains with explicit free-energy budgets and fidelity bounds.
Reinterpreted chromosome dynamics, Mendelian inheritance, and population genetics using statistical mechanics and constrained polymer physics.
Proved semiconservative replication as the unique physical resolution of antiparallel duplex templating, quantifying fidelity across discrimination, proofreading, and mismatch repair.
Unified gene regulatory mechanisms—including operons, chromatin accessibility, enhancers, and noncoding RNAs—into sequence-dependent free-energy barriers and gated occupancy states.
Established an axiomatic export bundle establishing that transmission genetics, linkage, and genome-wide association follow conservative thermodynamic constraints.

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Implication

Theoretical analysis demonstrates the physical and thermodynamic derivation of core genetic phenomena, highlighting a unified foundational model of biological inheritance.

Cite This Study

Jianming Wang (2026) studied this question.

synapsesocial.com/papers/6a7ec746b70b84ec8b9136df https://doi.org/10.5281/zenodo.21902528

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Implication

Theoretical analysis demonstrates the physical and thermodynamic derivation of core genetic phenomena, highlighting a unified foundational model of biological inheritance.

Genetics and the Genome: Inheritance and Variation of Information Topology (Volume II of the Axiomatization of Biology in the Global‑Realism Framework)

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Discussion

Implication

Cite This Study

Genetics and the Genome: Inheritance and Variation of Information Topology (Volume II of the Axiomatization of Biology in the Global‑Realism Framework)

Key Points

Discussion

Implication

Cite This Study

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