What question did this study set out to answer?

This study aims to characterize the time course and predictors of multi-organ failure (MOF) in adult patients with severe burns.

August 6, 2026European Burn JournalOpen Access

Multi-Organ Failure in Adult Patients Admitted to Intensive Care with Severe Burns—A Retrospective Cohort Study

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Retrospective cohort study identifies predictors of multi-organ failure in severe burn patients, indicating key risk factors.

This study aims to characterize the time course and predictors of multi-organ failure (MOF) in adult patients with severe burns.
Retrospective cohort study of adult patients with TBSA burns > 15% admitted to the ICU from 2016 to 2025.
Sequential Organ Failure Assessment (SOFA), DENVER2, and sepsis criteria were calculated at specified intervals during ICU admission.
Logistic regression models were utilized to identify variables associated with MOF.
131 patients included, with older age and more severe burns linked to MOF development.
MOF incidence peaked at day 5, while sepsis peaked at day 10.
Renal failure and the need for renal replacement therapy were rare but significantly associated with lower survival.

McIver et al. (2026) studied this question.

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