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August 6, 2026NutrientsOpen Access

Effects of Probiotic and Synbiotic Supplementation on Body Composition and Glucose Metabolism in Children and Adolescents with Overweight or Obesity: A Systematic Review and Meta-Analysis

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Authors

YTYe TaoSejong UniversityWWWei WangSejong UniversityYZYe ZhangSejong University

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Implication

Systematic review evaluates the impact of probiotics on body and glucose metrics in youth with obesity, suggesting modest BMI effects.

Key Points

  • This review aims to assess the impact of probiotic and synbiotic supplementation on body composition and glucose metabolism in children and adolescents with obesity.
  • Systematic review conducted per PRISMA guidelines
  • Included randomized controlled trials on probiotic or synbiotic supplementation
  • Outcomes assessed include BMI z-score, waist circumference, fasting glucose, and HOMA-IR.
  • Probiotic or synbiotic supplementation showed no significant reduction in BMI z-score (MD = −0.03, 95% CI −0.11 to 0.05) or waist circumference (MD = 0.60 cm, 95% CI −1.57 to 2.77)
  • A modest reduction in BMI was noted (MD = −0.91 kg/m2, 95% CI −1.81 to −0.01) but with low certainty
  • No significant effects were observed for fasting glucose, fasting insulin, or HOMA-IR.

Cite This Study

Tao et al. (2026) studied this question.

synapsesocial.com/papers/6a7437c8764cddc9499d557ahttps://doi.org/10.3390/nu18152539
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of synbiotic supplementation on metabolic profiles in children with obesity: a randomized double-blinded placebo-controlled trial2026 · 1 citations
  2. 2Effects of probiotics, prebiotics, and synbiotics on cardiometabolic risk factors in children and adolescents with overweight or obesity: a systematic review and Bayesian network meta-analysis2024 · 15 citations
  3. 3Effects of different exercise modalities and intensities on body composition in overweight and obese children and adolescents: a systematic review and network meta-analysis2023 · 32 citations
  4. 4The effects of synbiotic supplementation on some cardio-metabolic risk factors in overweight and obese children: a randomized triple-masked controlled trial2013 · 117 citations
  5. 5A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents2024 · 17 citations