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Probiotic and symbiotic supplementation significantly reduces total cholesterol, LDL, and triglyceride levels in individuals with overweight or obesity, with symbiotics demonstrating a greater lipid-lowering effect. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 16, 2026Obesity Reviews

Effect of Probiotic and Symbiotic Supplementation on Lipid Parameters in Individuals With Overweight and Obesity: A Systematic Review and Meta‐Analysis

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Authors

MRMarcelli de Oliveira RochaUniversidade Federal de Pelotas GMGabriel MessenburgerUniversidade Federal de Pelotas FNFernanda Ferreira NuñezUniversidade Federal de Pelotas

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Implication

Systematic review finds probiotics and symbiotics reduce cholesterol and triglycerides in individuals with overweight and obesity, suggesting potential health benefits.

Key Points

Evaluate the effects of probiotic and symbiotic supplementation on lipid parameters in individuals with overweight and obesity.
Systematic search of electronic databases including PubMed and Cochrane Library for RCTs up to April 2023.
Risk of bias assessed using Cochrane tool (RoB 2) and certainty of evidence assessed via GRADE methodology.
Included 28 out of 1363 articles in the meta-analysis.
Probiotics and symbiotics significantly reduced total cholesterol by MD = -0.09 mmol/L (95% CI: -0.16, -0.03).
LDL levels decreased by MD = -0.06 mmol/L (95% CI: -0.12, -0.01) and triglycerides by MD = -0.05 mmol/L (95% CI: -0.10, -0.01).
No significant effect on HDL levels (MD = 0.01 mmol/L; 95% CI: -0.01, 0.03), with symbiotics showing a greater reduction in cholesterol and triglycerides.

Cite This Study

Rocha et al. (2026) studied this question.

synapsesocial.com/papers/6a080a41a487c87a6a40c23c https://doi.org/10.1111/obr.70158

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Implication

Systematic review finds probiotics and symbiotics reduce cholesterol and triglycerides in individuals with overweight and obesity, suggesting potential health benefits.

Effect of Probiotic and Symbiotic Supplementation on Lipid Parameters in Individuals With Overweight and Obesity: A Systematic Review and Meta‐Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of Probiotic and Symbiotic Supplementation on Lipid Parameters in Individuals With Overweight and Obesity: A Systematic Review and Meta‐Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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