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December 1, 2015Current Protocols in Mouse Biology

Optimized Heart Sampling and Systematic Evaluation of Cardiac Therapies in Mouse Models of Ischemic Injury: Assessment of Cardiac Remodeling and Semi‐Automated Quantification of Myocardial Infarct Size

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Population

Mouse models of ischemic injury (myocardial infarction)

Design

Preclinical

Authors

MVMariana ValenteUniversidade de São PauloAAAna AraújoUniversidade do PortoTETiago EstevesEscola Superior de Saúde Egas Moniz

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Implication

Standardized ischemic LV sampling may reduce histological variability in mouse MI models; extends methodological rigor for preclinical cardiac research.

Structured PICO

P
Population
Mouse models of ischemic injury (myocardial infarction)
I
Intervention
Protocols for representative sampling of the ischemic mouse heart followed by morphometric analysis of the left ventricle
O
Outcome
Assessment of cardiac remodeling and semi-automated quantification of myocardial infarct sizesurrogate

This paper provides standardized methods for histo-morphometric evaluation of the ischemic mouse heart, aiming to reduce variability and misinterpretation in preclinical testing of cardiac therapies.

Cite This Study

Valente et al. (2015) studied this question.

synapsesocial.com/papers/6a744c2eb06f632524092f26https://doi.org/10.1002/9780470942390.mo140293
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial ischemia and reperfusion: a murine model1995 · 436 citations
  2. 2Tissue Inhibitor of Metalloproteinase‐2 Gene Delivery Ameliorates Postinfarction Cardiac Remodeling2011 · 25 citations
  3. 3Localization of Islet-1–Positive Cells in the Healthy and Infarcted Adult Murine Heart2012 · 92 citations
  4. 4MIQuant – Semi-Automation of Infarct Size Assessment in Models of Cardiac Ischemic Injury2011 · 55 citations
  5. 5Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches2007 · 313 citations