P4716Gender differences in ventricular conduction abnormalities and associated outcome among reduced heart failure patients

Introduction: Prolonged QRS duration and bundle brunch pattern are associated with increased mortality among heart failure patients, but gender differences in QRS duration and pattern and associated effect on outcomes are not well established. Purpose: To investigate the prognostic role of gender and intraventricular conduction defects (left and right bundle branch blocks (LBBB and RBBB, nonspecific intraventricular conduction delay (IVCD; QRS ≥110 ms, no BBB)and left anterior fascicular block (LAFB))in patients with chronic heart failure. Methods: We investigated clinical and electrocardiographic characteristics among 187 patients with heart failure and left ventricular ejection fraction ≤40%. Patients with cardiac resynchronization therapy were excluded. Results: Clinical variables and outcomes, after a mean follow-up of 22±12.5 months were analyzed in 187 patients with chronic heart failure (mean left ventricular ejection fraction was 31.3±9.25) and LBBB (n=48), IVCD (n=16), RBBB (n=15), LAFB (n=21), and no IVCDs (n=87). We analyzed relationship between QRS duration and all-cause mortality and investigate gender-QRS duration interaction.