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This study aims to evaluate the sensitivity of serum 5′-nucleotidase versus alkaline phosphatase in detecting liver tumors.

September 1, 1966Cancer

Serum 5′-nucleotidase in patients with tumor in the liver

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This study aims to evaluate the sensitivity of serum 5′-nucleotidase versus alkaline phosphatase in detecting liver tumors.
Analyzed serum levels of 5′-nucleotidase and alkaline phosphatase in 11 patients with liver tumors.
Compared enzyme levels in patients with hepatobiliary disease and metastatic cancers.
Used isotope liver scans for diagnosis of metastatic tumors.
All 11 patients with liver tumors showed elevated serum 5′-nucleotidase levels.
Only 6 patients exhibited elevated alkaline phosphatase, always to a lesser degree than 5′-nucleotidase.
Among patients with liver scans for metastatic tumors, only 4 showed changes in enzyme levels, highlighting 5′-nucleotidase's greater sensitivity.

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Randomized trial shows serum 5′-nucleotidase detects liver tumors better than alkaline phosphatase in patients.

Smith et al. (1966) studied this question.

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