What is the clinical evidence from this study?

Study design: Review. Population: Type 1 diabetes mellitus and diabetic cardiomyopathy.

April 19, 2020International Journal of Molecular SciencesOpen Access

Can We Prevent Mitochondrial Dysfunction and Diabetic Cardiomyopathy in Type 1 Diabetes Mellitus? Pathophysiology and Treatment Options

View Full Paper

Ask AI

Bookmark

Key result

This review summarizes the pathophysiology linking mitochondrial dysfunction to diabetic cardiomyopathy in type 1 diabetes mellitus and outlines potential therapeutic approaches to counteract it.

Why the study?

Chronic hyperglycemia in type 1 diabetes mellitus induces oxidative stress and mitochondrial dysfunction, which animal studies implicate in diabetic cardiomyopathy, prompting a review of this link and potential therapeutic approaches.

Design

Review

Authors

ACAleksandra CieluchPoznan University of Medical Sciences AUAleksandra UruskaPoznan University of Medical Sciences DZDorota Zozulińska‐ZiółkiewiczPoznan University of Medical Sciences

Discussion

Member takes

Implication

Mitochondrial therapies for T1DM cardiomyopathy remain hypothesis-generating; prospective human trials needed before clinical adoption.

Structured PICO

Population

Patients and animal models with type 1 diabetes mellitus at risk for or developing diabetic cardiomyopathy

Intervention

Therapeutic approaches counteracting the development of mitochondrial dysfunction and diabetic cardiomyopathy

This review summarizes the pathophysiology linking mitochondrial dysfunction to diabetic cardiomyopathy in type 1 diabetes and discusses potential therapeutic approaches.

Cite This Study

Cieluch et al. (2020) conducted a review in Type 1 diabetes mellitus and diabetic cardiomyopathy. This review summarizes the pathophysiology linking mitochondrial dysfunction to diabetic cardiomyopathy in type 1 diabetes mellitus and outlines potential therapeutic approaches to counteract it.

synapsesocial.com/papers/6a745475ae9b0728cddb6052 https://doi.org/10.3390/ijms21082852

View Full Paper

Ask AI

Bookmark

Can We Prevent Mitochondrial Dysfunction and Diabetic Cardiomyopathy in Type 1 Diabetes Mellitus? Pathophysiology and Treatment Options

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Can We Prevent Mitochondrial Dysfunction and Diabetic Cardiomyopathy in Type 1 Diabetes Mellitus? Pathophysiology and Treatment Options

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider