What question did this study set out to answer?

Identify novel pharmacogenetic determinants underlying interindividual variability in lung function response to inhaled glucocorticoids in patients with asthma.

September 26, 2011New England Journal of MedicineOpen Access

Genomewide Association between GLCCI1 and Response to Glucocorticoid Therapy in Asthma

View Full Paper

Ask AI

Bookmark

Authors

KTKelan G. TantisiraUniversity of San Diego JLJessica Lasky‐SuBrigham and Women's Hospital MHMichishige HaradaRIKEN Center for Integrative Medical Sciences

Discussion

Member takes

Implication

Genomewide association study reveals blunted response to inhaled glucocorticoids in asthma patients carrying a GLCCI1 variant, highlighting a pharmacogenetic basis for treatment failure.

Key Points

Identify novel pharmacogenetic determinants underlying interindividual variability in lung function response to inhaled glucocorticoids in patients with asthma.
Screened 534,290 single-nucleotide polymorphisms using a family-based algorithm to detect variants linked to lung function changes after inhaled glucocorticoid therapy.
Replicated candidate associations across four independent populations totaling 935 individuals and characterized functional cellular effects using luciferase reporter gene assays.
Identified a replicated pharmacogenetic association at GLCCI1 variant rs37972 (P=0.0007), which exists in complete linkage disequilibrium with rs37973 and reduces gene expression.
Treated individuals homozygous for the mutant rs37973 allele achieved only a 3.2±1.6% mean increase in FEV1 versus 9.4±1.1% in wild-type homozygotes, conferring higher risk of poor response (OR, 2.36; 95% CI, 1.27 to 4.41; P=0.0007 pooled) and explaining 6.6% of response variability.

Cite This Study

Tantisira et al. (2011) studied this question.

synapsesocial.com/papers/6a74557fa1ef36aabfdb5ee6 https://doi.org/10.1056/nejmoa0911353

View Full Paper

Ask AI

Bookmark

Implication

Genomewide association study reveals blunted response to inhaled glucocorticoids in asthma patients carrying a GLCCI1 variant, highlighting a pharmacogenetic basis for treatment failure.

Genomewide Association between GLCCI1 and Response to Glucocorticoid Therapy in Asthma

Discussion

Member takes

Implication

Key Points

Cite This Study

Genomewide Association between GLCCI1 and Response to Glucocorticoid Therapy in Asthma

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider