What question did this study set out to answer?

This study aims to investigate the cerebrovascular effects of nitrous oxide when combined with isoflurane during anesthesia.

July 1, 1995Acta Anaesthesiologica Scandinavica

Nitrous oxide is a potent cerebrovasodilator in humans when added to isoflurane. A transcranial Doppler study

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Why the study?

Does adding nitrous oxide to isoflurane alter cerebral blood flow velocity compared to isoflurane alone in lumbar laminectomy patients?

Population

n=20 lumbar laminectomy patients

Comparison

Isoflurane plus nitrous oxide over a dose range… vs Isoflurane alone over a dose range from 0.5 to…

Design

RCT, randomized either to receive isoflurane or isoflurane plus nitrous oxide

Authors

SSS. StrebelUniversity Hospital of Basel MKMark KaufmannUniversity of Basel LALuciano AnselmiEnte Ospedaliero Cantonale

Discussion

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Implication

Nitrous oxide addition to isoflurane raises CBFV dose-dependently; extends RCT evidence on anesthetic cerebrovascular interactions.

Key Points

This study aims to investigate the cerebrovascular effects of nitrous oxide when combined with isoflurane during anesthesia.
Twenty lumbar laminectomy patients randomized to receive isoflurane or isoflurane plus nitrous oxide.
Transcranial Doppler ultrasonography was used to measure cerebral blood flow velocity in the right middle cerebral artery.
The study analyzed effects over a dose range from 0.5 to 1.5 MAC.
At 1 MAC, CBFV decreased marginally in isoflurane alone and increased significantly with nitrous oxide (p<0.05).
At 1.5 MAC, no change was observed in isoflurane only, but a very significant increase occurred with nitrous oxide (exact p-value not stated).
The vasodilatory effect of nitrous oxide increased progressively with higher concentrations of isoflurane.

Structured PICO

Does adding nitrous oxide to isoflurane alter cerebral blood flow velocity compared to isoflurane alone in lumbar laminectomy patients?

Population

n=20 lumbar laminectomy patients

Intervention

Isoflurane plus nitrous oxide over a dose range from 0.5 to 1.5 MAC

Comparator

Isoflurane alone over a dose range from 0.5 to 1.5 MAC

Outcome

Cerebral blood flow velocity (CBFV) in the right middle cerebral artery (MCA) measured by transcranial Doppler (TCD) ultrasonographysurrogate

Adding nitrous oxide to isoflurane anesthesia significantly increases cerebral blood flow velocity in a dose-dependent manner.

Cite This Study

Strebel et al. (1995) studied this question.

synapsesocial.com/papers/6a7457634d9108bbdbdb619c https://doi.org/10.1111/j.1399-6576.1995.tb04143.x

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Nitrous oxide is a potent cerebrovasodilator in humans when added to isoflurane. A transcranial Doppler study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Nitrous oxide is a potent cerebrovasodilator in humans when added to isoflurane. A transcranial Doppler study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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