Why the study?
Does 3% inspired isoflurane added to nitrous oxide and oxygen attenuate the pressor response to intubation in ASA I patients?
Population
52 ASA I patients anaesthetized with thiopentone 4-6 mg.kg-1 and vecuronium 0.1 mg.kg-1
Comparison
3 min mask ventilation with nitrous oxide in… vs 3 min mask ventilation with nitrous oxide in…
Design
Other
Follow-up
Immediate (during 3-min ventilation and after intubation)
Authors
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May blunt intubation pressor response in low-risk patients; leaves open net benefit amid sympathetic activation.
Does 3% inspired isoflurane added to nitrous oxide and oxygen attenuate the pressor response to intubation in ASA I patients?
Adding isoflurane to nitrous oxide and oxygen during induction attenuates the pressor response to intubation despite causing sympathetic activation.
Randell et al. (1991) studied this question.
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