Key result
A 0D cardiopulmonary model accurately reproduces mouse RVP waveforms to infer ventricular function and pulmonary hemodynamics.
Why the study?
Comprehensive functional and hemodynamic characterization of the cardiopulmonary system in rodent models is often impractical and may require integrating multimodal measurements.
Effect estimate: r = 0.94
A 0D computational model successfully reproduced right ventricular pressure waveforms in mice, demonstrating the feasibility of digital twins for inferring cardiopulmonary hemodynamics.
May aid individualized mouse cardiopulmonary modeling; leaves open clinical translation and prospective validation.
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Kheyfets et al. (2026) studied Cardiopulmonary hemodynamics (n=28). 0D cardiopulmonary model was evaluated on Reproduction of RVP waveforms (maximum dP/dt) (r = 0.94). A 0D cardiopulmonary model adequately reproduced right ventricular pressure waveforms in mice (r = 0.94 for maximum dP/dt), enabling inference of ventricular function and pulmonary hemodynamics.
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